When one does not know Jesus Christ as their only means to Salvation in this world and in the one to come, then they are destined to perish, for the wages of sin is death (physical and spiritual) but the gift of God is eternal life through Jesus Christ, the Lord. Jesus is the Son of God, who paid the wages of our sin by His self sacrificial excruciating death on a Cross. But what if one has this foreknowledge of who Jesus Christ is and what He has done for the Salvation of mankind and still continues to reject this knowledge; then what? When one willfully rejects the knowledge of Christ, then there is no possible outcome but a sad one of being rejected by God Himself, for there is no other means to God the Father, except by believing in Jesus Christ.
Jesus Christ is The visa to God. Without Jesus’ stamp in the passport of our lives, the entry into God’s kingdom will be denied. God would have to reject us if we reject His Son.
Hosea 4:6 (KJV)
6 My people are destroyed for lack of knowledge: because thou hast rejected knowledge, I will also reject thee, that thou shalt be no priest to me: seeing thou hast forgotten the law of thy God, I will also forget thy children.